Are You Ready to Adopt?

We have a large selection of dogs and cats - all at one location! Our adoption fee includes spay/neuter, microchip, first two sets of shots and parasite preventative. Dogs are tested for heartworm and cats are tested for FIV/FeLeuk prior to adoption. Come check out all our great dogs and cats!

Make A Donation

Open Door relies 100% on donations from individuals, businesses and organizations in our community. Even a small donation will make a BIG difference! A $50 gift can go towards spaying or neutering a pet. Donations – large and small – can help a young kitten that needs special medication or help a dog get the immediate care that it needs to get adopted.

Join Our Volunteer Force

Whether you have all day or just a few hours, we are always in need of volunteers. You can help us make a lasting difference in the lives of the 350 cats and dogs we care for every day and you will get to work with some very dedicated and passionate people who care about the welfare of animals as much as you do.

Open Door Animal Sanctuary, founded in 1975, is the largest no-kill shelter in the greater St. Louis area and State of Missouri.  Open Door’s Mission is to provide homeless cats and dogs with the highest quality of life and a second chance to find a forever family.

We serve the community by taking in stray, abused, neglected and otherwise unwanted cats and dogs and placing them up for adoption. Each day we provide shelter, food, medical care and LOVE to more than 300 animals. Every animal that comes to us has a home and a second chance at life.


Dogs & Cats Housed & Cared For Daily


Dogs & Cats Rescued & Adopted Annually


Check out all the awesome events, programs, activities, and rescues happening at Open Door.

The 30th annual Purina Pet Parade is St. Louis’s largest annual pet event. The parade travels through historic Soulard, featuring […]